WHY WORK FOR ARCTURUS?

Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a global, late-stage clinical mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR™ mRNA Technology (samRNA) and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs to potentially treat ornithine transcarbamylase (OTC) deficiency, and cystic fibrosis, along with partnered programs including glycogen storage disease type III, and hepatitis B virus. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. Arcturus’ technologies are covered by its extensive patent portfolio (patents and patent applications issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations including, amongst others, Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., and the Cystic Fibrosis Foundation.

Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences. Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients.

THE OPPORTUNITY

Arcturus is seeking a highly motivated, well-organized, and skilled individual who can lead a diverse bioanalytical team. The incumbent must have a strong background in cell biology, bioanalytical assay development, in vitro screening assays, and be familiar with standard biochemical, cell and molecular biology techniques. The candidate should have experience working in a matrixed organization, and will play a key leadership role in the Bioanalytical Development group in the Department of Translational Biology, Exact title and responsibilities will be commensurate with experience.

RESPONSIBILITIES:

Manage daily activities of the Bioanalytical Development group

• Direct the development, execution, optimization, and troubleshooting of bioanalytical assays
• Provide technical expertise in study design, conduct, interpretation, and integration of data on cross-functional project teams
• Provide scientific monitoring and guidance on outsourcing studies for the method transfer, development, troubleshooting, qualification, validation and reports to support discovery and development.
• Supervise team members in generation of SOPs, experimental protocols, internal reports and manuscripts: present results at internal and external meetings or conferences
• Regularly interact with the Vice President and Project Lead(s) on all assigned projects
• Represent Bioanalytical on Development teams
• Develop and oversee pharmacodynamic assays for nonclinical and clinical programs
• Working with PK consultants provide PK support for toxicology and clinical studies
• Contribute to patent and/or publication preparation
• Contribute to regulatory submissions
• Build upon personal publication record and contribute to departmental internal and external influence.
• Responsible for general lab safety
• Responsible for the oversite of the tissue culture facility
• Perform all other related duties as assigned
• QUALIFICATIONS:
• PhD or Master’s degree in Biology or Chemistry Sciences
• Minimum of 10+ years of industry experience in biotech or biopharma companies or contract research organizations
• Proven expertise in leading and managing teams of scientists in a matrixed organization
• Proficient in tissue/cell culture, in vitro screening assays and standard techniques, such as ELISA, q-PCR, Western Blot, Quantigene, Ligand Binding assays, in vitro cell transfections, immunochemistry and reporter assays
• Proficient in assay development and qualification
• Experience with cell-based assay development, RNA technology, immunofluorescence, high content imaging, automation, and statistical evaluation of large data sets is required
• Experience with RNA therapeutics and vaccines preferred
• Experience with tissue distribution and GLP toxicology study analyses preferred
• Experience with nonclinical and clinical pharmacology preferred
• Ability to manage a team and direct the execution of experiments under tight timelines
• Excellent communication skills, ability to handle multiple projects and meet deadlines
• Effective time management and organization skills; meticulous record keeping skills
• Demonstrated ability to multitask and collaborate with scientists in a highly dynamic environment
• Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, JMP,LIMS etc., and with standard laboratory calculations.
• Experience with WinNonLin or other PK modeling software a plus
• Working in a biohazard laboratory or other laboratories known to contain radioactive or other potentially harmful chemicals.
• Continuous sitting, upward and downward flexion of neck; fine finger dexterity and light to moderate finger pressure to operate keyboard, equipment controls, pipetting and other office equipment.
• Frequent side-to-side turning of neck, walking, standing, bending and stooping, pushing/pulling, twisting at waist, moderate wrist torque to twist equipment knobs and dials; lifting objects weighing up to 20 lbs. from below waist to above shoulders and transporting.
• Occasional squatting, kneeling, reaching above and at shoulder height, moderate grasping to manipulate reference books and manuals; lifting objects weighing 20-35 lbs. from below waist to above shoulders and transporting distances up to 50 feet.
• This position requires working in a dynamic laboratory environment and coordinating the activities of laboratory personnel.

WHAT WE OFFER

At Arcturus Therapeutics, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family, and wellbeing journey while providing flexibility and resources to support their growth and aspirations. Our total rewards package includes:

• Full range of health benefits including Medical, Dental & Vision with 100% EMPLOYER PAID premiums for employee and family!
• 401k Match
• Employee Stock Purchase Program (ESPP)
• Competitive salaries and bonus plans plus equity via Stock Options
• Catered lunches
• Free variety of snacks and beverages
• Health and Wellness programs
• $100 Anniversary cash awards with opportunity to increase to $2000!
• Referral Bonuses
• On Campus Gym
• Company sponsored FUN events
• Education reimbursement

The anticipated salary range for candidates who will work in San Diego is $200,000 to $230,000.00.

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Arcturus Therapeutics is multi state employer and this salary range may not reflect positions that work in other states. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.

For a deeper dive into our company and corporate culture visit www.ArcturusRx.com

Arcturus is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.