Job description

Department: 3670020060 Biology
Job no: 515275
Employment type: Post Doc (Term)
Location: Manhattan, Kansas
Worksite: On-site requirement
Categories: Applied Sciences, Natural / Quantitative Sciences
Pay Grade: 001

About This Role:
The Division of Biology, Kansas State University, seeks a highly motivated scientist to investigate mechanisms of translational regulation in eukaryotes in the laboratory of Dr. Katsura Asano.

This project is funded by an NIH grant and aimed at identifying rate-limiting steps in start codon selection, using computational approaches. Specifically, the candidate has an expertise in computational work, in order to generate and analyze molecular dynamics simulations datasets. A method such as adaptive biasing force method is applied to evaluate the binding free energy and stepwise binding pathway in codon: anticodon binding in the ribosomal P-site. Specifically, the candidate is expected to independently reproduce the work described in the first paper listed below. The members of the Asano lab actively collaborate with computational biology experts world-wide. The selected candidate will be offered appropriate advice from these experts related to steps needed to do the work. The position starts as early as June 25 , 2023 and ends on June 22, 2024. The renewal of this position depends on funding availability.

To learn about our research, please refer to:
Takeru Kameda, Katsura Asano and Yuichi Togashi. Free Energy Landscape of RNA Binding Dynamics in Start Codon Recognition by Eukaryotic Ribosomal Pre-Initiation Complex (2021). Plos Comput. Biol. 17 , e1009068.
Yoshihiko Fujita, et al. (2022). Translational recoding by chemical modification of non-AUG start codon ribonucleotide bases. Science Advances 8 , eabm8501 .
Leiming Tang et al. (2017). Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide. Nucl. Acids Res . 45 , 11941-11953.

Why Join Us:
Kansas State University offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, paid time off - vacation, sick, and holidays. To see what benefits are available, please visit: https://www.k-state.edu/hcs/benefits

We Support Diversity and Inclusion:
Kansas State University embraces diversity and inclusion. The university actively seeks individuals who foster a collegial environment and cooperative interactions with coworkers, students, and others. The University is dedicated to promoting the Principles of Community .

What You'll Need to Succeed: Minimum Qualifications:
Master degree in physics, statistics, mathematics, computer science, molecular biology, biochemistry or related science field.
Basic coding skills in Python or C.
Basic knowledge of mechanics, thermodynamics, and statistical mechanics.
Some experience in linux (or other UNIX-like OS) system administration.

Preferred Qualifications:
Ph D Degree in physics, computational biosciences, or similar field
Experience in Python and C programming
Experience in high-performance computing
Experience in modeling and molecular dynamics simulation of biomolecules
Experience in handling genomics database including RNA-seq datasets

Other Requirements:
Applicants must be currently authorized to work in the United States at the time of employment

How to Apply: Please submit the following documents:
CV
Cover letter
Contact information for three professional references
online application
Resume

Screening of Applications Begins:
Immediately and continues until position is filled. For best consideration, apply by May 19, 2023.

Anticipated Hiring Salary Range:
$47500 annually

Equal Employment Opportunity:
Kansas State University is an Equal Opportunity Employer. All applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender, gender identity, age, national origin, disability or status as a protected veteran.

Background Screening Statement:
In connection with your application for employment, Kansas State University will procure a Background Screen on you as part of the process of considering your candidacy as an employee.

Advertised: May 12, 2023
Application Closes: Open until filled

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