Job description

POSITION SUMMARY:

• As part of the Analytical Research and Development (ARD) group in Biotherapeutics Pharmaceutical Sciences, we are seeking an enthusiastic, self-driven, and optimistic a B.S., M.S., or Ph.D. degree (with at least 7+, 5+, and 0-3 years of work experience, respectively) level candidate specializing in the protein expression, purification and charaterization.
• The successful candidate will provide support for LC-MS and LC-MS/MS method development and qualification in support of quantitation of mRNA expressed proteins in cells as well as in-depth structural elucidation of these proteins.
• As such, candidate should have in-depth understanding and hands-on experience with the expression, purification, enrichment, and characterization of antibodies, proteins, and/or vaccine products that includes commensurate technical knowledge and skills.
• Candidates should be comfortable working at the interface of analytical chemistry, biochemistry, cell biology, as well as interacting with cross-site research groups.
• Excellent written and communication skills, effective time-management, an innovative spirit, and the ability and desire to work both independently and collaboratively in a multidisciplinary, fast-paced, team-oriented environment are essential for the position.

POSITION RESPONSIBILITIES:

• Develop, qualify, and benchmark the LC-MS and/or LC-MS/MS quantitative method to monitor expression of proteins in cells post mRNA transfection.
• Develop novel strategies and methods with the latest UHPLC and MS technologies for more informative and efficient product characterization and process monitoring.

EDUCATION AND EXPERIENCE:

• Candidates should have a B.S. 7+ years work experience, M.S. 5+ years work experience, or Ph.D. 0-3 years work experience in chemistry, biochemistry or related field, and a primary focus on protein mass spectrometry, commensurate with graduate studies, postdoctoral research, and/or work experience.

TECHNICAL SKILLS REQUIREMENTS:

• Specialization in protein biochemistry and mass spectrometry (LC/MS, LC/MS/MS) is required.
• Extensive hands-on experience with protein purification and qualitative as well as quantitative protein analysis is required.
• Experience in cell culture and aseptic techniques is required.
• Extensive experience with well-established MS approaches and methods for the detailed structural analysis of therapeutic proteins is required.
• Familiarity with mRNA/DNA and protein therapeutics is highly desired with respect to structural characterization approaches, challenges and gaps, and regulatory principles.
• MS-based method development experience is highly desired for implementing more informative and efficient approaches to product characterization and process monitoring

PHYSICAL POSITION REQUIREMENTS:

• Position requires typical physical conditions for standard laboratory and office work
• Ability to perform mathematical calculations and ability to perform complex data analysis.

Required Skills:

• Ph.D. preferred,
• Advanced technology - Mass Spectrometry (Data Processing)
• Hit the ground Running
• mRNA Project, protein expression

Preferred Skills:

• Self-Starter
• Independent
• Fast learner
• Team Player (Collaborate with multiple teams)
• Cell Culture Experience
• Protein Purification, immunoprecipitation

Job Type: Contract

Pay: $35.00 - $40.00 per hour

Ability to commute/relocate:

• Chesterfield, MO: Reliably commute or planning to relocate before starting work (Required)

Education:

• Bachelor's (Required)

Experience:

• mass spectrometry (LC/MS, LC/MS/MS): 5 years (Required)
• protein analysis: 3 years (Preferred)

Work Location: In person

offroadmanagementgroup.com is the go-to platform for job seekers looking for the best job postings from around the web. With a focus on quality, the platform guarantees that all job postings are from reliable sources and are up-to-date. It also offers a variety of tools to help users find the perfect job for them, such as searching by location and filtering by industry. Furthermore, offroadmanagementgroup.com provides helpful resources like resume tips and career advice to give job seekers an edge in their search. With its commitment to quality and user-friendliness, offroadmanagementgroup.com is the ideal place to find your next job.