Senior Strain Engineering Scientist (V) – Strain Development
Full Time
Decatur, IL
Posted
Job description
Senior Strain Engineering Scientist (V) – Strain Development
Decatur
IL - Illinois
Research & Development
Job Description
Senior Strain Engineering Scientist (V) – Strain Development
ADM Research & Development
This is an exempt level position.
Position Summary:
The Cell Engineering group is recruiting a creative and highly-motivated scientist to join the Design Biology team as a subject matter expert (SME) in high-throughput (HTP) strain development. The successful candidate will develop innovative methods to build strains containing pooled, combinatorial DNA parts for yeast and bacteria while using state-of-the-art genetic engineering technologies. The goal of these complex strain libraries is to enable the rapid identification of advantaged genotypes for the bioproduction of small molecules using top-down high-throughput phenotypic screens. This team member will collaborate closely with SMEs in bioinformatics and automation while working with multiple bio-molecule project leaders to deliver strain libraries with desired specifications. This is a critical role that will enable a step change in strain design capability within ADM Cell Engineering. Scientists with experience working with industrially relevant non-model microorganisms are encouraged to apply.
Responsibilities:
These skills and experiences will be required for the candidate:
ADM Research & Development
This is an exempt level position.
Position Summary:
The Cell Engineering group is recruiting a creative and highly-motivated scientist to join the Design Biology team as a subject matter expert (SME) in high-throughput (HTP) strain development. The successful candidate will develop innovative methods to build strains containing pooled, combinatorial DNA parts for yeast and bacteria while using state-of-the-art genetic engineering technologies. The goal of these complex strain libraries is to enable the rapid identification of advantaged genotypes for the bioproduction of small molecules using top-down high-throughput phenotypic screens. This team member will collaborate closely with SMEs in bioinformatics and automation while working with multiple bio-molecule project leaders to deliver strain libraries with desired specifications. This is a critical role that will enable a step change in strain design capability within ADM Cell Engineering. Scientists with experience working with industrially relevant non-model microorganisms are encouraged to apply.
Responsibilities:
- Develop and use state-of-the-art synthetic biology methods for building complex DNA variant libraries (e.g. enzyme variants, multigenic expression cassettes) in microbial genomes
- Collaborate with the high-throughput automation team to ensure strain libraries fit specifications and that DNA parts are catalogued in LIMS
- Work with molecule project leaders to design and deliver genetically diverse libraries that meet strain KPI improvement goals
- Develop technologies to standardize strain engineering methods that increase efficiency measured by true positive rate (TPR) of strains identified from screens
- Determine the technical feasibility and execute strain library builds with increasing complexity (e.g. multi-enzyme pathways)
- Expand and optimize existing workflows for improved economics, success rate and turnaround time
- Assist with the bench-to-robot transfer of the technology developed
- Simultaneously work on multiple strain projects with different specifications
- Track genetic parts and strain designs using a customized LIMS system
- Contribute to a team-oriented, positive, safe and inclusive work environment
These skills and experiences will be required for the candidate:
- Ph.D. in molecular biology, biotechnology, biochemistry or related field with 3+ years of industry experience
- Track record developing high-throughput molecular biology workflows that were transferred to automated platforms
- Experience developing novel methods and troubleshooting molecular biology protocols to build large strain libraries
- Deep understanding of state-of-the-art genome editing technologies
- Experience working with large strain datasets derived from HTP screens
- Experience genetically engineering non-model industrial microorganisms including extremophilic yeast and/or bacteria
- Demonstrated success working within inter-disciplinary teams
- Excellent written and oral communication skills with both technical and non-technical personnel
- Ability to prioritize responsibilities and work effectively in a matrix environment
This position offers a complete benefit package, including 401K/ESOP, pension, health, life and dental insurance.
ADM requires the successful completion of a pre-employment drug screen and a background check.
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About ADM:
ADM unlocks the power of nature to enrich the quality of life. We're a premier global human and animal nutrition company, delivering solutions today with an eye to the future. We're blazing new trails in health and well-being as our scientists develop groundbreaking products to support healthier living. We're a cutting-edge innovator leading the way to a new future of plant-based consumer and industrial solutions to replace petroleum-based products. We're an unmatched agricultural supply chain manager and processor, providing food security by connecting local needs with global capabilities. And we're a leader in sustainability, scaling across entire value chains to help decarbonize our industry and safeguard our planet. From the seed of the idea to the outcome of the solution, we give customers an edge in solving the nutritional and sustainability challenges of today and tomorrow. Learn more at www.adm.com.
EEO
ADM is an equal opportunity employer and makes employment decisions without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability and veterans status.
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