Success Profile

Courageous
Results-driven
Proactive
Problem-Solver
Leadership
Team player

Position: 2023 Co-Op, Upstream MSAT

Location: Framingham, MA

Duration: June 2023 – Dec 2023

Note: Candidates must be available 40 hours per week, Monday-Friday

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi, Empowering Life

Discover your future…

Sanofi’s university opportunities offer exposure to a fast-paced and collaborative environment. Students work side-by-side with biopharmaceutical professionals, providing an opportunity to make an impact in the lives of patients around the globe. This Co-Op may lead to a full-time opportunity upon graduation based on successful performance reviews and final interview process. One of the goals of this program is to feed a leadership pipeline of top talent for our Sanofi Biologics full-time opportunities. Sanofi Biologics early career hiring launches your career to the next level through a targeted approach.

DEPARTMENT DESCRIPTION:

The job position is part of the Upstream team in the drug substance function within global Manufacturing Science & Technology (MSAT) and is based at the biologics hub in Framingham, MA. The MSAT mission is to enable the reliable supply of SC (Specialty Care) medicines by providing expert technical and scientific support to their licensure, ongoing commercial manufacturing, and life-cycle management activities.

The drug substance function within global MSAT is the owner of Life Cycle Management (LCM) of DS processes within the Sanofi biologics manufacturing network. We deliver innovative, robust, and cost-effective next generation processes and provide commercial manufacturing support. The function is responsible for tech transfer activities including process-fit gap assessment, process validation, dossier preparation, & PAI support to enable launch of new and LCM products. Our expansive portfolio covers 17 products, 5 modalities, 3 expression systems within 12 internal and external global sites in the US and EU. We will be supporting launch of 20 new products in the next 5 years including monoclonal and multi-specific antibodies, fusion proteins, antibody-drug conjugates, synthorins, and nanobodies. In recent years we have successfully established second-generation manufacturing processes with a continuous process platform. We are pursuing future innovations such as digital labs, factory of the future, and advanced-analytics-based process understanding and control.

Job Responsibilities

• Support commercial biotech manufacturing of mammalian cell culture and protein purification through experimental work and data analysis to support scale-up, mixing & mass transfer analysis, and process analytical technology.

• Work as part of a team, engaging other scientists with complementary skill sets in the field of Biopharmaceutics

• Generate documents (technical memos, protocols, reports, etc.) related to lab experiments.

• Co-ops will own a relevant capstone project to complete during the semester.

Basic Qualifications

• Must be currently enrolled as a student in an accredited undergraduate or graduate academic program

• Working toward a bachelor's or master’s degree in Chemical Engineering, Biochemistry, or equivalent

• 3.0/4.0 GPA is a minimum requirement

• Must have permanent US work authorization

Preferred Qualifications

• Basic understanding of mammalian cell culture

• Understanding of mass transport and building of system boundaries for optimization

• Experience in scripting in Matlab or Python

• Knowledge in Chemometrics and multivariate data analysis

Co-Op Project Description

Develop dynamic kLa models for small-scale bioreactors

The mass transfer coefficient, kLa determines the rate of gas transport between gas and liquid phases, and the method is used for oxygen uptake rate measurement and the prediction of oxygen demands. However, the current kLa measurement methodology is not accurate due to the high contribution of surface kLa in small-scale bioreactors, but the surface kLa is assumed as it is negligible. Here, we will develop

• Direct measurement of headspace DO (dissolved oxygen) as well as liquid phase DO in a small-scale bioreactor.

• Build a dynamic kLa model using headspace DO and liquid phase DO and estimate surface kLa and liquid phase kLa in a small-scale bioreactor.

• Apply and compare classic (apparent) kLa and dynamic kLa (liquid and surface kLa) using cell culture simulation.

Develop Raman spectroscopy models to predict metabolite concentrations and cell density using the Ambr250 (high throughput and miniaturized bioreactor), Raman PAT and Simca (MVDA analysis software). The Ambr Raman PAT models can be developed efficiently using the high throughput operations of Ambr250 and to minimize the model development time.

• The candidate will learn the Ambr250 operation for the Raman PAT and optimize Raman model parameters for metabolites and viable cell density in the mammalian cell culture process.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SG
#LI-GZ

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.